The champions take on QPR at the Etihad stadium, in a repeat of the dramatic ultimate fixture from last year in which Manchester City secured the Premier league title.
Mark Hughes’s team will be hoping to do one better than last year when QPR pushed Manchester City right to the final whistle.
Both of last season’s fixtures ended in 3-2 wins for City, although Rangers led in each game.
The London side have a good scoring record against the champions the last few fixtures, bagging 10 goals in their last four league and cup games away to City, three of which were at Maine Road.
Manchester City have the better of QPR overall with 21 wins out of the 48 previous meetings, compared to QPR’s 12 victories.
Good news for QPR as Manchester City are without injured trio Sergio Aguero, Gareth Barry and Micah Richards.
Coverage starts at 4:30pm on ESPN, with kick off at 5:30pm.